Whitehouse D B
Biochem Genet. 1984 Feb;22(1-2):51-63. doi: 10.1007/BF00499286.
Using polyacrylamide gel isoelectric focusing and standard specific hemolytic detection methods, genetic polymorphisms have been found in the sixth and seventh complement components (C6 and C7) in two laboratory groups of Common marmosets. The C6 locus is highly variable and the products of six alleles were observed; three C7 alleles were found. Comprehensive breeding data indicated that both sets of alleles are inherited in an autosomal codominant manner. Many of the C6 variants differed only by a minute charge interval. The C7 variant bands differed by large charge intervals and could only be clearly seen in plasmas that had been preincubated with neuraminidase. A linkage analysis of C6 and C7 phenotypes in three, two-generation families gives reasonable evidence that the two loci are linked in marmosets as they are in humans.
使用聚丙烯酰胺凝胶等电聚焦和标准特异性溶血检测方法，在普通狨猴的两个实验室群体中发现了第六和第七补体成分（C6和C7）的基因多态性。C6位点高度可变，观察到六个等位基因的产物；发现了三个C7等位基因。综合育种数据表明，两组等位基因均以常染色体共显性方式遗传。许多C6变体仅相差微小的电荷间隔。C7变体条带的电荷间隔差异很大，只有在与神经氨酸酶预孵育的血浆中才能清晰可见。对三个两代家庭中C6和C7表型的连锁分析提供了合理的证据，表明这两个位点在狨猴中与人一样是连锁的。
