Srivas K C
Prostaglandins Leukot Med. 1984 Feb;13(2):227-35. doi: 10.1016/0262-1746(84)90014-3.
Aqueous extracts of onion, garlic and ginger were found to inhibit aggregation induced by ADP, epinephrine, collagen and arachidonate in a dose-dependent manner in vitro. In the case of onion and garlic extracts relatively much higher volumes were need to bring about even a modest inhibition (by ca. 13-18%) of thromboxane synthesis in washed platelets from labelled AA. On the other hand a good correlation was found between the amounts of ginger extract needed to inhibit platelet aggregation and those to inhibit platelet thromboxane synthesis. Ginger extract reduced also platelet prostaglandin-endoperoxides. A dose-related inhibition of platelet thromboxane- and prostaglandin (PGF2 alpha, PGE2 and PGD2) synthesis was affected by ginger extract. Extracts of onion, garlic and ginger inhibited biosynthesis of prostacyclin in rat aorta from labelled AA. Ginger extract mildly inhibited the synthesis of prostacyclin from endogenous pool of AA in rat aorta; the other two extracts were without effect.
研究发现，洋葱、大蒜和生姜的水提取物在体外能以剂量依赖的方式抑制由二磷酸腺苷（ADP）、肾上腺素、胶原蛋白和花生四烯酸诱导的聚集。就洋葱和大蒜提取物而言，要对来自标记花生四烯酸（AA）的洗涤血小板中的血栓素合成产生哪怕是适度的抑制（约13 - 18%），都需要相对高得多的量。另一方面，发现抑制血小板聚集所需的生姜提取物量与抑制血小板血栓素合成所需的量之间存在良好的相关性。生姜提取物还能降低血小板前列腺素内过氧化物。生姜提取物对血小板血栓素和前列腺素（前列腺素F2α、前列腺素E2和前列腺素D2）合成有剂量相关的抑制作用。洋葱、大蒜和生姜的提取物抑制了大鼠主动脉中来自标记AA的前列环素的生物合成。生姜提取物轻度抑制大鼠主动脉中来自内源性AA池的前列环素的合成；另外两种提取物则无此作用。
