Osifo B O, Lukanmbi F A, Adeyokunnu A
Acta Haematol. 1984;71(5):299-303. doi: 10.1159/000206605.
The serum cobalamin, serum folate, erythrocyte folate concentrations and total leucocyte and neutrophil counts have been studied in sickle cell children (with HbSS) during the steady state. There was a significant reduction in serum cobalamin concentration with significant increases in both the total leucocyte count and neutrophil differential. A relationship was also observed between the serum cobalamin and erythrocyte folate. The lowest erythrocyte folate levels were observed in patients with the lowest serum cobalamin concentration. These abnormalities are discussed in relation to the possible role of cobalamin in the synthesis of erythrocyte folate polyglutamate and possible immunological role of cobalamin among these children. These results lend support to the view that daily cobalamin supplementation along with folate (which is being given) may prove beneficial to the sickle cell patients as it may lower the frequency and severity of infections.
对镰状细胞病患儿（HbSS型）病情稳定期的血清钴胺素、血清叶酸、红细胞叶酸浓度以及全白细胞和中性粒细胞计数进行了研究。血清钴胺素浓度显著降低，同时全白细胞计数和中性粒细胞分类均显著升高。还观察到血清钴胺素与红细胞叶酸之间存在关联。血清钴胺素浓度最低的患者红细胞叶酸水平最低。结合钴胺素在红细胞叶酸多聚谷氨酸合成中的可能作用以及钴胺素在这些儿童中的可能免疫作用，对这些异常情况进行了讨论。这些结果支持了这样一种观点，即每日补充钴胺素以及正在给予的叶酸可能对镰状细胞病患者有益，因为这可能降低感染的频率和严重程度。
