正常受试者因碳水化合物摄入导致丙戊酸盐诱导的高氨血症增加。

Increase of valproate-induced hyperammonemia in normal subjects by carbohydrate intake.

作者信息

Warter J M, Marescaux C, Chabrier G, Rumbach L, Micheletti G, Reitzer B, Hirsch E, Imler M

出版信息

Neurology. 1984 Nov;34(11):1487-9. doi: 10.1212/wnl.34.11.1487.

DOI:10.1212/wnl.34.11.1487

Abstract

Sodium valproate-induced hyperammonemia in normal subjects is increased by the intake of carbohydrates--rapidly or slowly absorbed sugars, given by mouth or IV injection. The hyperammonemia is maximal about 3 hours after carbohydrate administration. This relation between carbohydrate and ammonia metabolism has not been described previously.

摘要

正常受试者服用丙戊酸钠后发生的高氨血症，会因摄入碳水化合物（经口服或静脉注射给予的快速或缓慢吸收的糖类）而加重。高氨血症在给予碳水化合物后约3小时达到峰值。碳水化合物与氨代谢之间的这种关系此前尚未有过描述。