Khayat A, Dencker L
Acta Pharmacol Toxicol (Copenh). 1984 Aug;55(2):145-52. doi: 10.1111/j.1600-0773.1984.tb01977.x.
Distribution of inhaled radioactive metallic mercury vapour (203Hg0) in rats and Marmoset monkeys (Callithrix jacchus), with or without pretreatment by ethyl alcohol or aminotriazole (rat), was studied by means of whole-body autoradiography, microautoradiography and scintillation counting of excised organs. Metallic mercury is oxidized by the catalase-H2O2 complex (Complex I) to the ionic form (Hg2+) and is known to be accumulated and retained in organs such as lungs, liver, myocardium, and brain, apparently after local oxidation in these organs. To this list of organs can be added the whole respiratory tract (nasal mucosa, trachea, and bronchi), a number of endocrine organs such as adrenal cortex, thyroid, corpora lutea of the ovaries, and interstitial tissues of the testes, the uvea and retina of the eye, and the salivary glands. In the liver, a regionalized pattern of distribution corresponding to the periportal hepatocytes was observed. Similarly, the subcapsular parts of the adrenal cortex (mainly the zona glomerulosa) were responsible for most of the adrenal mercury oxidation and retention. These organs (liver, adrenal) thus have a reserve capacity to oxidize Hg0. This is apparent also by the fact that ethyl alcohol and aminotriazole (known catalase inhibitors)--which depress oxidation and retention in most organs and whole body and thus increase blood concentrations of Hg0--cause an increased retention in most liver and adrenal cells.
采用全身放射自显影、显微放射自显影以及对切除器官进行闪烁计数的方法，研究了吸入放射性金属汞蒸气（203Hg0）在大鼠和狨猴（绢毛猴）体内的分布情况，其中大鼠进行了乙醇或氨基三唑预处理。金属汞被过氧化氢酶 - H2O2复合物（复合物I）氧化成离子形式（Hg2 +），并且已知其在肺、肝、心肌和脑等器官中积累并滞留，显然是在这些器官中局部氧化之后。可以在这个器官列表中增加整个呼吸道（鼻粘膜、气管和支气管）、一些内分泌器官，如肾上腺皮质、甲状腺、卵巢黄体以及睾丸间质组织、眼葡萄膜和视网膜以及唾液腺。在肝脏中，观察到了与门静脉周围肝细胞相对应的区域化分布模式。同样，肾上腺皮质的被膜下部分（主要是球状带）是肾上腺汞氧化和滞留的主要部位。因此，这些器官（肝脏、肾上腺）具有氧化Hg0的储备能力。这一点也很明显，即乙醇和氨基三唑（已知的过氧化氢酶抑制剂）会抑制大多数器官和全身的氧化和滞留，从而增加Hg0的血药浓度，但会导致大多数肝脏和肾上腺细胞中的滞留增加。
