β-内酰胺类、磷霉素和妥布霉素联合使用对铜绿假单胞菌的协同活性。
Synergistic activities of combinations of beta-lactams, fosfomycin, and tobramycin against Pseudomonas aeruginosa.
作者信息
Takahashi K, Kanno H
出版信息
Antimicrob Agents Chemother. 1984 Nov;26(5):789-91. doi: 10.1128/AAC.26.5.789.
Abstract
The effects of antibiotic combinations against Pseudomonas aeruginosa infections frequently found in hospitalized patients were investigated. By means of an agar plate dilution checkerboard method, combinations of piperacillin-fosfomycin, cefoperazone-fosfomycin, and cefsulodin-fosfomycin were synergistic against 80.0, 85.0, and 82.6% of the strains tested. The mean fractional inhibitory concentration indices of piperacillin-fosfomycin, cefoperazone-fosfomycin, and cefsulodin-fosfomycin were 0.48, 0.42, and 0.46, respectively. The synergistic activities of these combinations were enhanced by the addition of a small amount of tobramycin, 0.25 micrograms/ml.
摘要
研究了抗生素联合用药对住院患者中常见的铜绿假单胞菌感染的影响。通过琼脂平板稀释棋盘法，哌拉西林-磷霉素、头孢哌酮-磷霉素和头孢磺啶-磷霉素组合对80.0%、85.0%和82.6%的受试菌株具有协同作用。哌拉西林-磷霉素、头孢哌酮-磷霉素和头孢磺啶-磷霉素的平均分数抑制浓度指数分别为0.48、0.42和0.46。添加少量（0.25微克/毫升）妥布霉素可增强这些组合的协同活性。
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