Asherson R A, Lanham J G, Hull R G, Boey M L, Gharavi A E, Hughes G R
Clin Exp Rheumatol. 1984 Jan-Mar;2(1):75-9.
Two patients with lupus erythematosus and renal vein thrombosis are described. Both patients had the "lupus anti-coagulant" in their serum. It is postulated that in these patients the clotting tendency could be favoured by a cross reaction of the "lupus anti-coagulant" with phospholipids in the endothelial cell membrane, resulting in inhibition of prostacyclin release.
本文描述了两名患有红斑狼疮和肾静脉血栓形成的患者。两名患者血清中均存在“狼疮抗凝物”。据推测,在这些患者中,“狼疮抗凝物”与内皮细胞膜中的磷脂发生交叉反应,可能会促进凝血倾向,从而抑制前列环素的释放。