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系统性红斑狼疮中的肾静脉血栓形成:与“狼疮抗凝物”的关联。

Renal vein thrombosis in systemic lupus erythematosus: association with the "lupus anticoagulant".

作者信息

Asherson R A, Lanham J G, Hull R G, Boey M L, Gharavi A E, Hughes G R

出版信息

Clin Exp Rheumatol. 1984 Jan-Mar;2(1):75-9.

PMID:6442640
Abstract

Two patients with lupus erythematosus and renal vein thrombosis are described. Both patients had the "lupus anti-coagulant" in their serum. It is postulated that in these patients the clotting tendency could be favoured by a cross reaction of the "lupus anti-coagulant" with phospholipids in the endothelial cell membrane, resulting in inhibition of prostacyclin release.

摘要

本文描述了两名患有红斑狼疮和肾静脉血栓形成的患者。两名患者血清中均存在“狼疮抗凝物”。据推测,在这些患者中,“狼疮抗凝物”与内皮细胞膜中的磷脂发生交叉反应,可能会促进凝血倾向,从而抑制前列环素的释放。

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