细菌脂多糖诱导的干扰素的细胞起源
Cellular origin of interferon induced by bacterial lipopolysaccharide.
作者信息
Maehara N, Ho M
出版信息
Infect Immun. 1977 Jan;15(1):78-83. doi: 10.1128/iai.15.1.78-83.1977.
Abstract
Bacterial lipopolysaccharide (LPS) induces interferons with different properties in mouse macrophages and B lymphocytes. Macrophage interferon is labile at 56 degrees C and is neutralized by anti-mouse fibroblast interferon at a dilution of 1:6,142. B cell interferon is more heat stable and is neutralized by the same antiserum only at a dilution of 1:276. Serum obtained early (1 h) after an intravenous injection of 100 mug of LPS resembled macrophage interferon, whereas serum obtained at later times resembled more and more B cell interferon. The diverse cellular origin of LPS-induced interferon may explain the broad hyporesponsiveness produced by LPS in animals.
摘要
细菌脂多糖（LPS）在小鼠巨噬细胞和B淋巴细胞中诱导产生具有不同特性的干扰素。巨噬细胞干扰素在56℃时不稳定，在稀释至1:6,142时可被抗小鼠成纤维细胞干扰素中和。B细胞干扰素更耐热，仅在稀释至1:276时才能被相同抗血清中和。静脉注射100μg LPS后早期（1小时）获得的血清类似于巨噬细胞干扰素，而后期获得的血清越来越类似于B细胞干扰素。LPS诱导的干扰素的不同细胞来源可能解释了LPS在动物中产生的广泛低反应性。
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