人淋巴细胞培养物中针对腮腺炎病毒产生γ干扰素的免疫特异性反应
Immune-specific production of gamma interferon in human lymphocyte cultures in response to mumps virus.
作者信息
Nakayama T
出版信息
Infect Immun. 1983 May;40(2):486-92. doi: 10.1128/iai.40.2.486-492.1983.
Abstract
The production of interferon (IFN) was investigated in human peripheral lymphocyte cultures stimulated by mumps virus. IFN-alpha and IFN-gamma were produced in lymphocyte cultures from immune donors. However, no IFN-gamma was produced in lymphocyte cultures from nonimmune donors. IFN-alpha was produced by B lymphocytes, and IFN-gamma was produced by T lymphocytes. An increase in the production of IFN-gamma resulted from the mixture of autologous macrophages in T-lymphocyte cultures. The production of IFN-gamma by T lymphocytes was found to depend on prior, possibly cellular, immunity.
摘要
研究了腮腺炎病毒刺激的人外周血淋巴细胞培养物中干扰素（IFN）的产生情况。免疫供体的淋巴细胞培养物中产生了IFN-α和IFN-γ。然而，非免疫供体的淋巴细胞培养物中未产生IFN-γ。IFN-α由B淋巴细胞产生，IFN-γ由T淋巴细胞产生。T淋巴细胞培养物中加入自体巨噬细胞后，IFN-γ的产生增加。发现T淋巴细胞产生IFN-γ取决于先前可能的细胞免疫。
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