系统性红斑狼疮中的抑制细胞缺陷：与天然DNA结合的关系。
Suppressor cell defect in SLE: relationship to native DNA binding.
作者信息
Krakauer R S, Clough J D, Alexander T, Sundeen J, Sauder D N
出版信息
Clin Exp Immunol. 1980 Apr;40(1):72-6.
Abstract
Recent evidence suggests the presence of a suppressor T cell defect in systemic lupus erythematosus. We confirm the presence of such a defect and find a strong quantitative correlation between the loss of suppressor T cell function and the activity of SLE as measured by the presence of antibodies to native DNA. In addition, the serum of patients with active SLE contains a soluble factor which when incubated with normal peripheral blood lymphocytes induces a suppressor T cell defect. These data are consistent with the suppressor cell defect being involved in the propagation and possible the pathogenesis of SLE, and suggests a positive feedback mechanism whereby a suppressor cell defect results in autoantibodies including antibody to suppressor cells.
摘要
近期证据表明系统性红斑狼疮存在抑制性T细胞缺陷。我们证实了这种缺陷的存在，并发现抑制性T细胞功能丧失与通过抗天然DNA抗体的存在所衡量的SLE活动度之间存在很强的定量相关性。此外，活动性SLE患者的血清含有一种可溶性因子，当与正常外周血淋巴细胞一起孵育时，会诱导抑制性T细胞缺陷。这些数据与抑制性细胞缺陷参与SLE的传播以及可能的发病机制相一致，并提示了一种正反馈机制，即抑制性细胞缺陷导致自身抗体包括抗抑制性细胞抗体的产生。
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本文引用的文献
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