同时给药后兔组织不溶性组分中无机汞和硒的行为
Behavior of inorganic mercury and selenium in insoluble fractions of rabbit tissues after simultaneous administration.
作者信息
Naganuma A, Kosugi K, Imura N
出版信息
Toxicol Lett. 1981 Apr;8(1-2):43-8. doi: 10.1016/0378-4274(81)90136-3.
The existing states of mercury and selenium in the insoluble fractions of perfused rabbit liver and kidney were studied by gel filtration on Sephadex G-200 at 24 h after i.v. injection of mercuric chloride and/or sodium selenite. After simultaneous injection of mercuric chloride and selenite, both mercury and selenium existed in a high-molecular weight (HMW) fraction of the liver-insoluble fraction at a molar ratio of 1:1, there was little change in gel filtration pattern of the kidney-insoluble fraction. Equimolar amounts of mercury and selenium existed in each subcellular fraction of rabbit liver. Most of the mercury and selenium accumulated in the rabbit liver, not only those in the soluble fraction but also those in the insoluble fraction, appeared to co-exist in the HMW fraction at a molar ratio of 1:1 at 24 h after simultaneous administration.
静脉注射氯化汞和/或亚硒酸钠24小时后，通过在Sephadex G - 200上进行凝胶过滤，研究了灌注兔肝脏和肾脏不溶性部分中汞和硒的存在状态。同时注射氯化汞和亚硒酸钠后，肝脏不溶性部分的高分子量（HMW）组分中汞和硒以1:1的摩尔比存在，肾脏不溶性部分的凝胶过滤模式变化不大。兔肝脏的每个亚细胞组分中汞和硒的量相等。在同时给药24小时后，大部分在兔肝脏中积累的汞和硒，不仅是可溶性部分中的，还有不溶性部分中的，似乎都以1:1的摩尔比共存于HMW组分中。
Zotero 插件