风湿性多肌痛和颞动脉炎中的纤维蛋白（原）溶解：与疾病活动相关性的初步研究结果
Fibrin(ogen)olysis in polymyalgia rheumatica and temporal arteritis: preliminary findings on association with disease activity.
作者信息
Grau R G, Kassan S S, Franks J J, Kaplan H, Walker S H, Tan E M
出版信息
Ann Rheum Dis. 1984 Oct;43(5):721-4. doi: 10.1136/ard.43.5.721.
Postulating an increased production of fibrin(ogen)olytic degradation products (FDP) and an abnormality of fibrinogen metabolism in polymyalgia rheumatica (PMR) and temporal arteritis (TA), we studied 16 PMR/TA patients and 10 control subjects using a sensitive radioimmunoassay for a specific type of FDP, namely, fibrin(ogen)-related D-antigen. Median serum D-antigen levels were increased five-fold in those 11 PMR/TA patients who were untreated compared with control subjects. In the five PMR/TA patients who were treated with prednisone the median D-antigen levels were not significantly different from those of the healthy controls. D-antigen concentration correlated significantly (r = 0.83) with ESR in the seven untreated PMR patients. In PMR patients prednisone therapy was followed by a reduction of serum D-antigen levels.
鉴于风湿性多肌痛（PMR）和颞动脉炎（TA）中纤维蛋白（原）溶解降解产物（FDP）生成增加以及纤维蛋白原代谢异常的假设，我们使用一种针对特定类型FDP（即纤维蛋白（原）相关D抗原）的灵敏放射免疫分析法，对16例PMR/TA患者和10名对照受试者进行了研究。与对照受试者相比，11例未接受治疗的PMR/TA患者的血清D抗原水平中位数升高了五倍。在接受泼尼松治疗的5例PMR/TA患者中，D抗原水平中位数与健康对照者无显著差异。在7例未接受治疗的PMR患者中，D抗原浓度与红细胞沉降率（ESR）显著相关（r = 0.83）。在PMR患者中，泼尼松治疗后血清D抗原水平降低。
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