Palacios R, Möller G
J Exp Med. 1981 May 1;153(5):1360-5. doi: 10.1084/jem.153.5.1360.
Concanavalin A (Con-A)-induced suppressor T cells were found to respond to T cell growth factor (TCGF) by proliferation. TCGF abrogated the suppressor activity exerted by these cells on phytohemagglutinin (PHA)- and alloantigen- induced lymphocyte proliferation and on pokeweed mitogen (PWM)-driven immunoglobulin secretion. The Con-A-activated suppressor T cells absorbed the TCGF activity, preincubation of these active suppressor cells with TCGF abolished their suppressor activity and addition of increasing numbers of Con-A-activated T cells reverted the abrogator,/ effect of TCGF. Altogether, these findings suggest that Con-A-induced suppressor T cells exert their function by decreasing the available levels of TCGF. Cyclosporin-A (CYA), which is known to inhibit the expression of receptors for TCGF on T cells, also inhibited the suppressor activity as determined in both indicator systems, namely PHA- or alloantigen-induced DNA synthesis and PWM-induced immunoglobulin synthesis. CYA made Con-A-treated T cells unresponsive to TCGF and unable to absorb the growth factor, supporting the notion that CYA inhibits the expression of TCGF receptors on T cells, a mechanism by which this drug seems to abrogate Con-A-induced suppressor T cell function.
发现刀豆球蛋白A（Con - A）诱导的抑制性T细胞通过增殖对T细胞生长因子（TCGF）作出反应。TCGF消除了这些细胞对植物血凝素（PHA）和同种异体抗原诱导的淋巴细胞增殖以及对商陆有丝分裂原（PWM）驱动的免疫球蛋白分泌所施加的抑制活性。Con - A激活的抑制性T细胞吸收了TCGF活性，将这些活性抑制细胞与TCGF预孵育消除了它们的抑制活性，并且添加越来越多的Con - A激活的T细胞可逆转TCGF的消除作用。总之，这些发现表明Con - A诱导的抑制性T细胞通过降低可用的TCGF水平发挥其功能。环孢菌素A（CYA）已知可抑制T细胞上TCGF受体的表达，在两个指示系统中（即PHA或同种异体抗原诱导的DNA合成以及PWM诱导的免疫球蛋白合成）所测定的抑制活性也受到抑制。CYA使Con - A处理的T细胞对TCGF无反应且无法吸收生长因子，支持了CYA抑制T细胞上TCGF受体表达的观点，这似乎是该药物消除Con - A诱导的抑制性T细胞功能的一种机制。
