Clot J, Guilhou J J, Andary M
J Invest Dermatol. 1982 Apr;78(4):313-5. doi: 10.1111/1523-1747.ep12507392.
T cell subsets bearing Fc-receptors for either IgG (TG) or IgM (TM), and suppressor cell activity of peripheral blood mononuclear cells on in vitro lymphoproliferative responses were studied in patients with untreated psoriasis. The proportions of TG and TM cells were unmodified in 15 patients compared to 15 control subjects studied in parallel experiments. The concanavalin A-induced suppressor cell activity, as well as the spontaneous suppressor cell function of in vitro short-lived adherent cells, were in the normal range for 7 out of 8 psoriatic patients investigated. The data argue against the possibility that a generalized suppressor cell defect occurs in psoriasis.
在未经治疗的银屑病患者中，研究了携带针对IgG（TG）或IgM（TM）的Fc受体的T细胞亚群，以及外周血单个核细胞对体外淋巴细胞增殖反应的抑制细胞活性。与在平行实验中研究的15名对照受试者相比，15名患者的TG和TM细胞比例未改变。在研究的8名银屑病患者中，有7名患者的刀豆球蛋白A诱导的抑制细胞活性以及体外短期贴壁细胞的自发抑制细胞功能在正常范围内。这些数据表明银屑病不太可能存在全身性抑制细胞缺陷。
