每日两次服用西咪替丁不会增加胃内细菌菌群。
Twice-daily cimetidine does not increase gastric bacterial flora.
作者信息
Bourne J T, Mountford R A, Barry R E
出版信息
Postgrad Med J. 1984 Jul;60(705):464-6. doi: 10.1136/pgmj.60.705.464.
Abstract
Thirty patients with peptic ulcer (20 duodenal, 10 gastric) underwent glucose-hydrogen (H2) breath tests before and after 6 weeks treatment with cimetidine, 400 mg twice daily. For the group as a whole, basal breath H2 and integrated H2 output over a 2.5 hr test period was unchanged by cimetidine treatment. We conclude that there was no evidence of significant gastric bacterial colonization following twice daily cimetidine treatment.
摘要
30例消化性溃疡患者（十二指肠溃疡20例，胃溃疡10例）在接受西咪替丁治疗（每日2次，每次400mg）6周前后进行了葡萄糖-氢气（H2）呼气试验。对于整个研究组，西咪替丁治疗后基础呼气H2以及2.5小时测试期内的累积H2排出量均未改变。我们得出结论，每日2次西咪替丁治疗后没有显著胃细菌定植的证据。
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Cimetidine is unlikely to increase formation of intragastric N-nitroso-compounds in patients taking a normal diet.西咪替丁不太可能在正常饮食的患者中增加胃内N-亚硝基化合物的形成。
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Hydrogen and methane production in man.人体中氢气和甲烷的产生
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Breath-hydrogen test for small-intestinal bacterial colonisation.
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