每日两次服用西咪替丁不会增加胃内细菌菌群。
Twice-daily cimetidine does not increase gastric bacterial flora.
作者信息
Bourne J T, Mountford R A, Barry R E
出版信息
Postgrad Med J. 1984 Jul;60(705):464-6. doi: 10.1136/pgmj.60.705.464.
Abstract
Thirty patients with peptic ulcer (20 duodenal, 10 gastric) underwent glucose-hydrogen (H2) breath tests before and after 6 weeks treatment with cimetidine, 400 mg twice daily. For the group as a whole, basal breath H2 and integrated H2 output over a 2.5 hr test period was unchanged by cimetidine treatment. We conclude that there was no evidence of significant gastric bacterial colonization following twice daily cimetidine treatment.
摘要
30例消化性溃疡患者（十二指肠溃疡20例，胃溃疡10例）在接受西咪替丁治疗（每日2次，每次400mg）6周前后进行了葡萄糖-氢气（H2）呼气试验。对于整个研究组，西咪替丁治疗后基础呼气H2以及2.5小时测试期内的累积H2排出量均未改变。我们得出结论，每日2次西咪替丁治疗后没有显著胃细菌定植的证据。
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Intragastric acidity, bacteria, nitrite, and N-nitroso compounds before, during, and after cimetidine treatment.西咪替丁治疗前、治疗期间及治疗后的胃内酸度、细菌、亚硝酸盐和N-亚硝基化合物。
Lancet. 1982 May 15;1(8281):1091-5. doi: 10.1016/s0140-6736(82)92277-2.
3
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Lancet. 1981 Sep 12;2(8246):550-2. doi: 10.1016/s0140-6736(81)90939-9.
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Cimetidine is unlikely to increase formation of intragastric N-nitroso-compounds in patients taking a normal diet.西咪替丁不太可能在正常饮食的患者中增加胃内N-亚硝基化合物的形成。
Lancet. 1981 Feb 21;1(8217):408-10. doi: 10.1016/s0140-6736(81)91791-8.
5
Effect of cimetidine on the gastric bacterial flora.西咪替丁对胃内细菌菌群的影响。
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