Cobb W E, Lamberton R P, Jackson I M
Clin Chem. 1984 Sep;30(9):1558-60.
Using a new three-site immunoradiometric assay for thyrotropin (TSH), we measured concentration of this hormone in the serum of 47 patients with hyperthyroidism and 46 controls. The mean and range of serum TSH concentration was significantly lower in thyrotoxic than in control subjects, and it was possible to correctly identify 96% of thyrotoxic patients on the basis of a serum TSH concentration less than 0.5 milli-int. unit/L. We conclude that such measurement is highly sensitive for distinguishing hyperthyroid from normal subjects, and that the lower limit of normal for TSH in serum is about 0.5 milli-int. unit/L.
我们采用一种新的促甲状腺激素（TSH）三点免疫放射分析方法，测定了47例甲状腺功能亢进患者和46例对照者血清中该激素的浓度。甲状腺毒症患者血清TSH浓度的均值和范围显著低于对照者，根据血清TSH浓度低于0.5毫国际单位/升，能够正确识别96%的甲状腺毒症患者。我们得出结论，这种测定方法在区分甲状腺功能亢进患者与正常受试者方面具有高度敏感性，血清TSH的正常下限约为0.5毫国际单位/升。
