大鼠泌乳期乳腺分离腺泡中葡萄糖代谢的调控。油酸对葡萄糖利用和脂肪生成的影响。
Control of glucose metabolism in isolated acini of the lactating mamary gland of the rat. Effects of oleate on glucose utilization and lipogenesis.
作者信息
Robinson A M, Williamson D H
出版信息
Biochem J. 1978 Mar 15;170(3):609-13. doi: 10.1042/bj1700609.
Abstract
Oleate (1mM) had only small inhibitory effects on glucose utilization and lipogenesis in acini isolated from rat mammary gland. Esterification of [1-14C]oleate was unaffected by insulin but were decreased by 60% by acetoacetate (2mM). Glycerol (1mM), but not insulin, relieved this inhibition. These experiments provide further support for the role of acetoacetate in regulating substrate utilization by the gland.
摘要
油酸（1毫摩尔）对从大鼠乳腺分离出的腺泡中的葡萄糖利用和脂肪生成只有微小的抑制作用。[1-¹⁴C]油酸的酯化不受胰岛素影响，但在乙酰乙酸（2毫摩尔）作用下降低了60%。甘油（1毫摩尔）而非胰岛素可缓解这种抑制作用。这些实验进一步支持了乙酰乙酸在调节乳腺底物利用方面的作用。
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