Stewart F A, Denekamp J
Br J Radiol. 1978 Apr;51(604):307-16. doi: 10.1259/0007-1285-51-604-307.
The response of an experimental fibrosarcoma to combined heat and X rays has been assessed using delay in tumour regrowth. No thermal sensitization was observed for one hour of heating at 41.5 degrees C. A thermal enhancement ratio of 1.4 to 1.5 was seen for one hour of heating at 42.5 or 43.5 degrees C immediately after irradiation. The importance of the sequence and time interval between the two modalities was tested using a constant heat treatment of 42.5 degrees C for one hour. Heating was most effective when given after irradiation, with little change in TER for an interval of a half to six hours. When heat preceded the irradiation the pattern was more complex, with no sensitization at half, one, and six hours, but with a significant effect at two and three hours. The degree of sensitization often depended upon the X-ray dose, being lower below X-ray doses of about 20 Gy. The therapeutic advantage of the combined treatment was assessed by comparison with previously published results for skin reactions. No therapeutic benefit was found for treatments when heat and X-rays were separated by one hour or less. A therapeutic gain factor of about 1.3 was observed for heat given two to six hours after irradiation of this fibrosarcoma.
利用肿瘤再生长延迟评估了实验性纤维肉瘤对热与X射线联合治疗的反应。在41.5℃加热1小时未观察到热增敏现象。在照射后立即于42.5℃或43.5℃加热1小时，热增强比为1.4至1.5。采用42.5℃持续加热1小时的方式测试了两种治疗方式的先后顺序和时间间隔的重要性。加热在照射后进行时最为有效，在半小时至6小时的时间间隔内热增强比变化不大。当加热先于照射时情况更为复杂，在半小时、1小时和6小时时无增敏现象，但在2小时和3小时时有显著效果。增敏程度通常取决于X射线剂量，在约20 Gy以下的X射线剂量时较低。通过与先前发表的皮肤反应结果进行比较，评估了联合治疗的治疗优势。当热与X射线间隔1小时或更短时间时，未发现治疗益处。对于该纤维肉瘤，在照射后2至6小时给予热疗时观察到约1.3的治疗增益因子。
