间歇性跛行：患病率及危险因素
Intermittent claudication: prevalence and risk factors.
作者信息
Hughson W G, Mann J I, Garrod A
出版信息
Br Med J. 1978 May 27;1(6124):1379-81. doi: 10.1136/bmj.1.6124.1379.
Abstract
Risk factors for intermittent claudication (IC) were studied in 54 patients--that is, all patients with IC on the lists of two general practices--and 108 controls. Smoking was the factor most strongly associated with the development of IC, but systolic and diastolic blood pressures and concentrations of triglyceride, urate, and fibrinogen were all significantly higher among the patients with IC than the controls. The presence of more than one factor appeared to be associated with a multiplicative increase in risk. Cholesterol, an important risk factor for ischaemic heart disease, was not associated with an increased risk of IC. IC was present in about 2% of the men and 1% of the women, who were aged 45-69 years. These findings suggest that IC, a common and disabling manifestation of atheroslcerosis, may be largely preventable.
摘要
对54例患者（即两家全科诊所名单上所有患有间歇性跛行（IC）的患者）和108名对照者进行了间歇性跛行的危险因素研究。吸烟是与IC发生最密切相关的因素，但IC患者的收缩压、舒张压以及甘油三酯、尿酸盐和纤维蛋白原浓度均显著高于对照组。存在一种以上因素似乎与风险的成倍增加有关。胆固醇是缺血性心脏病的重要危险因素，但与IC风险增加无关。在45至69岁的男性中，IC的患病率约为2%，女性约为1%。这些发现表明，IC作为动脉粥样硬化常见且致残的表现，在很大程度上可能是可以预防的。
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