赭曲霉毒素C在体内转化为赭曲霉毒素A。
Conversion of ochratoxin C into ochratoxin A in vivo.
作者信息
Fuchs R, Hult K, Peraica M, Radić B, Plestina R
出版信息
Appl Environ Microbiol. 1984 Jul;48(1):41-2. doi: 10.1128/aem.48.1.41-42.1984.
The conversion of ochratoxin C to ochratoxin A was studied in rats after oral and intravenous administration. The concentration of ochratoxin A in the blood as a function of time was the same after oral administration of equivalent amounts of either ochratoxin C or ochratoxin A. The maximum ochratoxin A concentrations were measured 60 min after administration. Given intravenously, ochratoxin C was also converted to ochratoxin A. Maximum concentrations were reached after 90 min. It is concluded that ochratoxin C is readily converted to ochratoxin A after both oral and intravenous administration. There is reason to believe that a comparable toxicity of the two toxins is based upon this conversion and that only interference with the biotransformation mechanisms may cause a difference in their toxicity.
在大鼠经口和静脉给药后，研究了赭曲霉毒素C向赭曲霉毒素A的转化。口服等量的赭曲霉毒素C或赭曲霉毒素A后，血液中赭曲霉毒素A的浓度随时间变化的情况相同。给药后60分钟测得赭曲霉毒素A的最大浓度。静脉注射时，赭曲霉毒素C也会转化为赭曲霉毒素A。90分钟后达到最大浓度。结论是，经口和静脉给药后，赭曲霉毒素C都能迅速转化为赭曲霉毒素A。有理由相信，这两种毒素具有相当的毒性是基于这种转化，只有干扰生物转化机制才可能导致它们毒性的差异。
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