Nishioka K, Kobayashi Y, Katayama I, Sano S
Arch Dermatol Res. 1984;276(4):224-8. doi: 10.1007/BF00414232.
Reactivity of scleroderma fibroblasts to lymphoid cell-derived fibroblast growth factor (FGF) was assessed in this study. The fibroblasts from the sclerotic lesion failed to respond to FGF, whereas those from scleroedematous lesions responded equally to normal fibroblast. Response of the fibroblast from sclerotic lesion was also lower than that of the fibroblast from mature scar. Fibroblasts obtained from three different layers of healthy skin, papillary dermis, reticular dermis, and reticular-subcutaneous layer, responded equally to FGF, whereas the fibroblast of reticular dermis from sclerotic lesion failed to respond to FGF. It is suggested that the fibroblast of reticular dermis in scleroderma is variously activated by some unknown factors, so that they do not have enough reserve to respond to further stimuli.
本研究评估了硬皮病成纤维细胞对淋巴细胞源性成纤维细胞生长因子（FGF）的反应性。硬化性病变部位的成纤维细胞对FGF无反应，而硬肿性病变部位的成纤维细胞对正常成纤维细胞的反应相同。硬化性病变部位的成纤维细胞反应也低于成熟瘢痕部位的成纤维细胞。从健康皮肤的三个不同层次（乳头层真皮、网状层真皮和网状皮下层）获取的成纤维细胞对FGF反应相同，而硬化性病变部位的网状层真皮成纤维细胞对FGF无反应。提示硬皮病中网状层真皮的成纤维细胞被一些未知因素不同程度地激活，以至于它们没有足够的储备来应对进一步的刺激。
