Shefchyk S J, Jell R M, Jordan L M
Exp Brain Res. 1984;56(2):257-62. doi: 10.1007/BF00236281.
The evidence suggests that the mesencephalic locomotor region (MLR) may not be a unitary region since anatomical and functional variations in the descending projections are clearly indicated. Reversible cooling of midline reticular structures can effectively block locomotion evoked by stimulation of lateral MLR (L3.5-4) sites while not significantly affecting the locomotion evoked from more medial MLR (L2-2.5) sites. In contrast, locomotion evoked by stimulation of the medial MLR sites is blocked by cooling of the ipsilateral lateral brainstem region which corresponds to the pontomedullary strip (PLS). Ipsilateral PLS cooling was not effective for blocking lateral MLR evoked locomotion, and contralateral PLS cooling was not effective for blocking either medial or lateral MLR evoked stepping. The evidence indicates that the lateral MLR relays through medial reticular nuclei while the medial MLR sites relay largely through the lateral brainstem structures often referred to as the PLS.
有证据表明，中脑运动区（MLR）可能并非一个单一的区域，因为下行投射中的解剖学和功能变化已得到明确显示。对中线网状结构进行可逆性冷却能够有效阻断由刺激外侧MLR（L3.5 - 4）部位所诱发的运动，而对由更内侧MLR（L2 - 2.5）部位诱发的运动影响并不显著。相比之下，刺激内侧MLR部位所诱发的运动可通过冷却同侧对应于脑桥延髓带（PLS）的外侧脑干区域来阻断。同侧PLS冷却对于阻断外侧MLR诱发的运动无效，而对侧PLS冷却对于阻断内侧或外侧MLR诱发的迈步均无效。有证据表明，外侧MLR通过内侧网状核进行中继，而内侧MLR部位则主要通过通常被称为PLS的外侧脑干结构进行中继。
