Vizzotto L, Ferrario V F, Molinari-Tosatti M P, Morini M, Miani A
Int J Tissue React. 1984;6(3):243-9.
The sizes and numbers of subcutaneous adipose-tissue fat cells were determined in obese patients, some of whom had undergone severe weight reduction induced by a jejuno-ileal bypass operation, and others a moderate thinning by a reducing diet, for comparison with those in normals. The size-class distribution of the fat cells suggests a morphoquantitative, dynamic interpretation of the two known forms of obesity, one being of moderate degree and called hypertrophic, the other more severe and called hyperplastic. The hypertrophic obese condition is characterized by a bimodal size-distribution curve of the adipocytes, similar to the curve in normal individuals. In both the normal and the hypertrophic obese, ponderal variations displace this curve forwards or backwards without altering its shape. By contrast, the hyperplastic obese shows a flat size-distribution curve without discernible modes. The smallest size-class of fat cells are the most sensitive to weight-reduction process and hypotrophize so much that they can no longer be recognized as adipocytes in histological sections; thus the size-distribution curve for hyperplastic obese individuals losing weight changes in shape from uniform to bimodal. The relationship which expresses the mean fat cell diameter as a function simultaneously of the initial weight and of ponderal variation was also studied, and tested by multiple regression analysis.
研究了肥胖患者皮下脂肪组织脂肪细胞的大小和数量，其中一些患者通过空肠回肠旁路手术实现了大幅减重，另一些患者通过节食实现了适度体重减轻，以便与正常人进行比较。脂肪细胞的大小分类分布表明，对两种已知的肥胖形式可以进行形态定量的动态解释，一种是中度肥胖，称为肥大性肥胖，另一种更严重，称为增生性肥胖。肥大性肥胖状况的特征是脂肪细胞的大小分布曲线呈双峰状，类似于正常个体的曲线。在正常人和肥大性肥胖者中，体重变化会使这条曲线向前或向后移动，而不会改变其形状。相比之下，增生性肥胖者的大小分布曲线是平的，没有明显的峰值。最小尺寸类别的脂肪细胞对减重过程最敏感，会发生严重萎缩，以至于在组织学切片中无法再被识别为脂肪细胞；因此，体重减轻的增生性肥胖个体的大小分布曲线形状会从均匀变为双峰状。还研究了将平均脂肪细胞直径同时表示为初始体重和体重变化函数的关系，并通过多元回归分析进行了检验。
