Ohrt V
Acta Ophthalmol (Copenh). 1984 Aug;62(4):603-16. doi: 10.1111/j.1755-3768.1984.tb03973.x.
A prospective study of the eyes of 75 diabetic women during the course of 100 pregnancies is presented as a contribution to the, as yet, still unresolved question concerning the influence of pregnancy on diabetic retinopathy. Fifty patients in the material had a retinopathy prior to pregnancy, proliferations were present in 2 of them. During the course of the pregnancy, proliferative changes developed in 4 patients, and a background retinopathy developed in a further 4 patients. Special interest is placed on the transitory changes in the retinopathy that occurs in a number of these patients. In the present material this has occurred in 23 patients, all of whom had a retinopathy. This is especially apparent in the form of soft exudates, haemorrhages and retinal oedema. In marked cases a characteristic feature was an obvious capillary change. This transitory capillaropathy is considered as being the cause of this temporary increase in the severity of the retinopathy. The changes regressed in all of the 23 patients. The results confirm that pregnancy can hardly be considered to influence the further course of a background retinopathy. Even though the question as to whether pregnancy can influence the course of a proliferative retinopathy still remains open, evaluation of both the present and previous materials suggest that pregnancy by and large does not aggravate the 'average' progression of a proliferative diabetic retinopathy.
本文对75名糖尿病女性在100次妊娠过程中的眼部情况进行了前瞻性研究，旨在为尚未解决的妊娠对糖尿病视网膜病变影响的问题提供参考。研究对象中50名患者在妊娠前就患有视网膜病变，其中2人有增殖性病变。在妊娠过程中，4名患者出现了增殖性变化，另有4名患者出现了背景性视网膜病变。特别值得关注的是，许多患者的视网膜病变出现了短暂性变化。在本研究对象中，23名患有视网膜病变的患者出现了这种情况。这在软性渗出、出血和视网膜水肿形式中尤为明显。在明显的病例中，一个特征性表现是明显的毛细血管变化。这种短暂性毛细血管病变被认为是视网膜病变严重程度暂时增加的原因。所有23名患者的病变均有所消退。结果证实，妊娠几乎不会影响背景性视网膜病变的进一步发展。尽管妊娠是否会影响增殖性视网膜病变的发展这一问题仍未明确，但对本研究及以往资料的评估表明，总体而言，妊娠不会加重增殖性糖尿病视网膜病变的“平均”进展。
