胰岛素依赖型青少年起病型糖尿病视网膜病变的患病率——一项荧光素血管造影研究。

The prevalence of retinopathy in insulin-dependent juvenile-onset diabetes mellitus--a fluorescein-angiographic study.

作者信息

Jerneld B, Algvere P

出版信息

Acta Ophthalmol (Copenh). 1984 Aug;62(4):617-30. doi: 10.1111/j.1755-3768.1984.tb03974.x.

DOI:10.1111/j.1755-3768.1984.tb03974.x

Abstract

A fluorescein-angiographic study was performed comprising all 171 insulin-dependent diabetics with debut at less than or equal to 40 years of age who were census registered on the island of Gotland 1981-82. Children under 15 years of age were excluded. The overall prevalence of diabetic retinopathy was 66%, being 11% at 0-5 years duration of diabetes, 42% at 6-10 years, 84% at 11-15 years, 90% at 16-30 years and 100% after 30-years duration. Proliferative retinopathy was first seen after 11 years duration, it had a prevalence of 18% and was twice as common in females as in males. Neovascularization was seen in 25% of patients with IDDM debut at less than or equal to 20 years of age and in only 7% of those with IDDM debut at 21-40 years (P less than 0.01). Pigment epithelial defects were found in 91 subjects (56%).

摘要

对1981 - 1982年在哥特兰岛进行人口普查登记的所有171例发病年龄小于或等于40岁的胰岛素依赖型糖尿病患者进行了荧光素血管造影研究。排除15岁以下儿童。糖尿病视网膜病变的总体患病率为66%，糖尿病病程0 - 5年时为11%，6 - 10年时为42%，11 - 15年时为84%，16 - 30年时为90%，病程30年后为100%。增殖性视网膜病变在病程11年后首次出现，患病率为18%，女性的患病率是男性的两倍。在发病年龄小于或等于20岁的胰岛素依赖型糖尿病患者中，25%出现了新生血管形成，而在发病年龄为21 - 40岁的患者中，只有7%出现新生血管形成（P<0.01）。在91名受试者（56%）中发现了色素上皮缺损。