Perry R L, Satin A J, Barth W H, Valtier S, Cody J T, Hankins G D
Department of Obstetrics and Gynecology, Wilford Hall Medical Center, Lackland AFB, TX 78236-5300, USA.
Am J Obstet Gynecol. 1996 May;174(5):1590-3. doi: 10.1016/s0002-9378(96)70611-7.
Our purpose was to determine the relationship among plasma oxytocin levels, metabolic clearance rate of oxytocin, and uterine activity in gravid women undergoing labor induction.
Ten women receiving oxytocin for labor induction and agreeing to participate had blood sampled before initiation of oxytocin and at different levels of uterine pressure. Samples were analyzed with 200 microliter extracts from 1 ml of plasma with an oxytocin radioimmunoassay. The intraassay coefficient of variation was < 3%. Sensitivity of the assay was 1.5 pg/ml. Pharmacokinetic parameters including plasma levels and metabolic clearance rates were calculated. Data were analyzed with the paired t test and linear and logistic regression.
Mean oxytocin levels and metabolic clearance rates were 26.6 pg/ml and 7.97 ml/min. There was no correlation between changes in oxytocin level and metabolic clearance rate. Increases in infusion rates were correlated with increases in oxytocin levels (r = 0.71, p < 0.001). Cervical dilatation and uterine contraction pressures did not correlate with oxytocin levels.
Peripheral plasma levels of oxytocin may not accurately reflect uterine activity or progress in labor. Plasma levels of oxytocin may merely reflect the rate of oxytocin infusion.
我们的目的是确定引产孕妇的血浆催产素水平、催产素代谢清除率和子宫活动之间的关系。
10名接受催产素引产并同意参与研究的女性，在催产素开始使用前以及子宫压力处于不同水平时采集血样。用1ml血浆中的200微升提取物通过催产素放射免疫测定法对样本进行分析。测定内变异系数<3%。该测定法的灵敏度为1.5pg/ml。计算包括血浆水平和代谢清除率在内的药代动力学参数。数据采用配对t检验以及线性和逻辑回归进行分析。
催产素平均水平和代谢清除率分别为26.6pg/ml和7.97ml/min。催产素水平变化与代谢清除率之间无相关性。输注速率的增加与催产素水平的增加相关（r = 0.71，p < 0.001）。宫颈扩张和子宫收缩压力与催产素水平无关。
外周血浆催产素水平可能无法准确反映子宫活动或产程进展。血浆催产素水平可能仅反映催产素的输注速率。
