Pecora A A, Chiesa J C, Alloy A M, Santoro J, Lazarus B
Gastrointest Endosc. 1984 Oct;30(5):284-8. doi: 10.1016/s0016-5107(84)72419-9.
Fiberoptic upper gastrointestinal endoscopy has become an accepted procedure with recognized and acceptable complication rates. Recently, significant hypoxemia during upper gastrointestinal endoscopy has been identified. This report evaluates changes in arterial blood gases and investigates the effects of drugs, smoking, and length of procedure. Upper gastrointestinal endoscopy was performed on 60 patients--15 patients in four different groups. Group I and II were smokers and nonsmokers who received sedation; groups III and IV were smokers and nonsmokers who received no sedation. A significant drop in PaO2 was noted in each group. Sedation, length of procedure, or smoking did not affect the PaO2 levels significantly. No significant change in PaCO2 was noted in any of the four groups. A V/Q mismatch related to vasospasm and/or bronchospasm is proposed as the main reason for the hypoxemia.
纤维光学上消化道内镜检查已成为一种被认可的操作，其并发症发生率是公认且可接受的。最近，已发现上消化道内镜检查期间出现显著低氧血症。本报告评估动脉血气的变化，并研究药物、吸烟和检查时长的影响。对60例患者进行了上消化道内镜检查，分为四个不同组，每组15例。第一组和第二组为接受镇静的吸烟者和非吸烟者；第三组和第四组为未接受镇静的吸烟者和非吸烟者。每组均发现动脉血氧分压（PaO2）显著下降。镇静、检查时长或吸烟对PaO2水平无显著影响。四组中任何一组的动脉血二氧化碳分压（PaCO2）均无显著变化。提出与血管痉挛和/或支气管痉挛相关的通气/血流比例失调是低氧血症的主要原因。
