Fujimoto S, Mizoi K, Yoshimoto T, Suzuki J
Surg Neurol. 1984 Nov;22(5):449-54. doi: 10.1016/0090-3019(84)90301-x.
Using the "canine model of the completely ischemic brain regulated with a perfusion method," the effects on cerebral ischemia of vitamin E, which is known to act as an antioxidant, were investigated. After pretreatment with vitamin E by oral or intravenous administration, cerebral blood flow was reduced to 1/10th the normal state and, 1 hour later, allowed to return to normal. Subsequent changes in electrical activity were observed, and the effects of vitamin E were evaluated. In the control group, no recovery of electrical activity was seen. In the groups given vitamin E, the recovery time was significantly shortened in the dogs given 30 mg/kg of vitamin E intravenously. Furthermore, in the groups treated with vitamin E, distinct recovery of electroencephalographic potentials at 3 hours after recirculation was apparent. These effects were more favorable in the case of intravenous administration than in the case of oral administration. These experimental results indicate that the administration of vitamin E is effective in protecting the brain from cerebral ischemia.
采用“通过灌注法调控的完全缺血性脑犬模型”，研究了已知具有抗氧化作用的维生素E对脑缺血的影响。通过口服或静脉给药对维生素E进行预处理后，将脑血流量降低至正常状态的1/10，1小时后使其恢复正常。观察随后的电活动变化，并评估维生素E的作用。在对照组中，未观察到电活动恢复。在给予维生素E的组中，静脉注射30mg/kg维生素E的犬的恢复时间显著缩短。此外，在接受维生素E治疗的组中，再灌注后3小时脑电图电位明显恢复。静脉给药的效果比口服给药更有利。这些实验结果表明，给予维生素E可有效保护大脑免受脑缺血的影响。
