Shaddock L C, Hamernik R P, Axelsson A
Am J Otolaryngol. 1984 Mar-Apr;5(2):99-107. doi: 10.1016/s0196-0709(84)80028-9.
The vascular anatomy of the chinchilla cochlea was quantitatively analyzed and compared in animals exposed to 155- or 160-dB impulse noise at normal (37 degrees C) and elevated (40 degrees C) body temperatures. Vascular changes persisted 45 days after noise exposure in all experimental animals. Six variables were most susceptible to change in one or more of the vessels studied: 1) irregularities in the vessel lumen, 2) plasma spaces between red blood cells (RBCs) and the vessel wall, 3) columns of RBCs, 4) variability in density of RBCs, 5) pigment clumps in the stria vascularis, and 6) perivascular cells compressing the vessel lumen. These vascular changes, which indicate a reduction in blood flow, were present throughout the length of the cochlea, with a tendency toward maximum change in areas of maximum hair cell loss. There was no evidence in the vascular results to support an interaction between noise and increased body temperature. However, the cochleograms from the experimental animals indicate that at the 160-dB exposure level the noise and high temperature may have interacted to increase hair cell loss.
对正常体温（37摄氏度）和升高体温（40摄氏度）下暴露于155或160分贝脉冲噪声的灰鼠耳蜗的血管解剖结构进行了定量分析和比较。噪声暴露后45天，所有实验动物的血管变化持续存在。六个变量在研究的一种或多种血管中最易发生变化：1）血管腔不规则；2）红细胞（RBC）与血管壁之间的血浆间隙；3）红细胞柱；4）红细胞密度变化；5）血管纹中的色素团块；6）压缩血管腔的血管周围细胞。这些表明血流减少的血管变化在耳蜗全长都存在，在毛细胞损失最大的区域有变化最大的趋势。血管结果中没有证据支持噪声与体温升高之间存在相互作用。然而，实验动物的耳蜗电图表明，在160分贝暴露水平下，噪声和高温可能相互作用增加了毛细胞损失。
