Axelsson A, Dengerink H
Dept. of Audiology, University of Gothenburg, Sweden.
Hear Res. 1987 Dec;31(2):183-91. doi: 10.1016/0378-5955(87)90125-0.
This paper compiles the results from seven experiments which have investigated noise exposure effects on histological measures of the cochlear vasculature and red blood cells. Two of these studies included at least two experimental conditions and all evaluated numerous histological parameters in several cochlear vessels. The combined results suggest that noise has a consistent general effect of reducing apparent cochlear blood flow as indicated by decreased RBC density, increased aggregation of RBCs, increased variability in RBC density, decreased number of RBC columns, increased vessel lumen irregularity and encroachment of perivascular cells upon the lumen wall. When considered at the level of the individual vessels, however, inconsistent results were observed. Fewer effects were noted in experiments which permitted animals to survive after the noise exposure than in those which sacrificed the animals immediately. Impulse noise resulted in more frequent vascular sequelae than did continuous noise. Further, impulse noise more frequently influenced vessels of the external wall than did continuous noise.
本文汇总了七项实验的结果，这些实验研究了噪声暴露对耳蜗血管系统和红细胞组织学指标的影响。其中两项研究包含至少两种实验条件，且均评估了多条耳蜗血管中的众多组织学参数。综合结果表明，噪声具有一致的总体效应，即会降低表观耳蜗血流量，表现为红细胞密度降低、红细胞聚集增加、红细胞密度变异性增加、红细胞柱数量减少、血管腔不规则性增加以及血管周围细胞向管腔壁的侵入。然而，在个体血管层面上，观察到的结果并不一致。与那些在噪声暴露后立即处死动物的实验相比，在允许动物存活的实验中观察到的影响较少。脉冲噪声比连续噪声导致更频繁的血管后遗症。此外，脉冲噪声比连续噪声更频繁地影响外壁血管。
