Hopkins R, Wood L E, Sinclair N M
Clin Pharmacol Ther. 1984 Dec;36(6):788-95. doi: 10.1038/clpt.1984.258.
Exposure to tobacco smoke is measured by a variety of invasive and noninvasive techniques. Our purpose was to examine how well some of these measures correlated when obtained simultaneously from the same subjects. On three occasions, six subjects were studied while they were smoking a single cigarette after 24 hr of abstinence. There were positive correlations between increases in heart rate and plasma nicotine concentrations and between percentage carboxyhemoglobin and exhaled carbon monoxide. Although residual cotinine was readily detected in samples of plasma before the subjects smoked, there was an increase in mean levels, with a peak approximately 1 hr after smoking. Urinary concentrations of nicotine, cotinine, and nicotine-1'-N-oxide and thiocyanate levels in plasma and saliva were essentially unchanged by smoking a single cigarette. Data on smoke generation and nicotine retention in cigarette butts correlated poorly with all other measures of smoke uptake.
接触烟草烟雾可通过多种侵入性和非侵入性技术进行测量。我们的目的是研究当从同一受试者同时获得这些测量值时，其中一些测量值之间的相关性如何。在三个不同时段，对六名受试者进行了研究，他们在戒烟24小时后吸了一支烟。心率增加与血浆尼古丁浓度之间以及羧基血红蛋白百分比与呼出一氧化碳之间存在正相关。尽管在受试者吸烟前的血浆样本中很容易检测到残留可替宁，但平均水平有所增加，在吸烟后约1小时达到峰值。吸一支烟对血浆和唾液中的尼古丁、可替宁、尼古丁-1'-N-氧化物的尿液浓度以及硫氰酸盐水平基本没有影响。关于香烟烟雾产生和烟头中尼古丁留存的数据与所有其他烟雾吸入测量值的相关性很差。
