Muranaka H, Higashi E, Itani S, Shimizu Y
Kyoto Senbai Hospital, Japan.
Int Arch Occup Environ Health. 1988;60(1):37-41. doi: 10.1007/BF00409377.
In a cross-sectional study on 236 individuals in Japan (174 males, 62 females; 149 smokers, 87 non-smokers) plasma nicotine (pnic), cotinine (pcot) and thiocyanate (pSCN), urinary creatinine ratios of nicotine (unic), cotinine (ucot) and thiocyanate (uSCN) as well as carboxyhemoglobin (COHb) and expired carbon monoxide (COex) were determined. All tobacco smoke uptake parameters (TSUP) were significantly elevated in smokers as compared to nonsmokers. The discriminant power (smokers vs nonsmokers) rank in the following order: ucot approximately pcot approximately unic greater than pSCN approximately COHb approximately pnic greater than COex approximately uSCN. All parameters except for pnic are significantly correlated with the self-reported number of cigarettes smoked per day. The reason for the poor correlation of pnic with daily cigarette consumption is the short half-life of pnic coupled with the arbitrary time of blood drawing in relation to the last time of smoking.
在一项针对日本236名个体（174名男性，62名女性；149名吸烟者，87名非吸烟者）的横断面研究中，测定了血浆尼古丁（pnic）、可替宁（pcot）和硫氰酸盐（pSCN）、尿中尼古丁（unic）、可替宁（ucot）和硫氰酸盐（uSCN）的肌酐比值以及碳氧血红蛋白（COHb）和呼出一氧化碳（COex）。与非吸烟者相比，吸烟者的所有烟草烟雾摄取参数（TSUP）均显著升高。判别能力（吸烟者与非吸烟者）排序如下：ucot≈pcot≈unic＞pSCN≈COHb≈pnic＞COex≈uSCN。除pnic外，所有参数均与自我报告的每日吸烟量显著相关。pnic与每日香烟消费量相关性较差的原因是pnic半衰期短，加上采血时间相对于上次吸烟时间的随意性。
