Kolosova N G, Shorin Iu P, Kulikov V Iu
Biull Eksp Biol Med. 1981 Apr;91(4):436-7.
Prolonged cold adaptation in rats (+4-6 degrees C) is associated with phasic changes in lipid peroxidation. On the 7th day the quantity of liquid peroxidation products in the liver and lungs and the ability of liver lipids to take part in the ascorbate-dependent peroxidation were increased. Meanwhile the antioxidant activity of lipids was decreased. On the 30th and 49th days there was no difference in the data obtained. This evidenced the formation of adaptation which was characterized by an essential rise in the antioxidant activity of liver lipids, by their decreased ability to get oxidized in the presence of ascorbate and iron, by a reduced amount in the liver and lungs of the peroxidation products (control levels). Activation of lipid peroxidation is considered as a necessary prerequisite for the formation of the specialized adaptation mechanisms.
大鼠在+4 - 6摄氏度环境下的长期冷适应与脂质过氧化的阶段性变化有关。在第7天，肝脏和肺中液体过氧化产物的量以及肝脏脂质参与抗坏血酸依赖性过氧化的能力增加。与此同时，脂质的抗氧化活性降低。在第30天和第49天，所获得的数据没有差异。这证明了适应性的形成，其特征是肝脏脂质的抗氧化活性显著提高，在抗坏血酸和铁存在下其氧化能力降低，肝脏和肺中过氧化产物的量减少（对照水平）。脂质过氧化的激活被认为是形成专门适应机制的必要前提。
