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早期经历对大鼠行为和大脑不对称性发育影响中的性别差异。

Sex differences in the effects of early experience on the development of behavioral and brain asymmetries in rats.

作者信息

Camp D M, Robinson T E, Becker J B

出版信息

Physiol Behav. 1984 Sep;33(3):433-9. doi: 10.1016/0031-9384(84)90166-5.

DOI:10.1016/0031-9384(84)90166-5
PMID:6514832
Abstract

The influence of early experience (preweaning handling) on the development of several postural/motor asymmetries (side bias in an open field, turn preference in a T-maze, amphetamine-induced rotational behavior, tail pinch-induced asymmetries) and the lateralization of brain dopamine was studied in adult male and female rats. In many cases the adult patterns of behavioral and brain asymmetries were modified by early handling in a sexually dimorphic manner. In addition, the direction of postural/motor asymmetries was very much task-dependent, especially in females. We conclude that: early experience may modify the development of behavioral and brain asymmetries; sex differences in asymmetries are very common; early handling may affect males and females differently; and different measures of postural/motor asymmetries may reflect different and multiple brain asymmetries.

摘要

研究了早期经历(断奶前处理)对成年雄性和雌性大鼠几种姿势/运动不对称性(旷场中的侧偏好、T 迷宫中的转向偏好、苯丙胺诱导的旋转行为、夹尾诱导的不对称性)以及脑多巴胺侧化发育的影响。在许多情况下,行为和脑不对称性的成年模式以性别二态性方式被早期处理所改变。此外,姿势/运动不对称性的方向非常依赖于任务,尤其是在雌性大鼠中。我们得出结论:早期经历可能会改变行为和脑不对称性的发育;不对称性中的性别差异非常普遍;早期处理对雄性和雌性的影响可能不同;姿势/运动不对称性的不同测量方法可能反映不同的和多种脑不对称性。

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