Fomon S J, Rogers R R, Ziegler E E, Nelson S E, Thomas L N
Pediatr Res. 1984 Dec;18(12):1233-8. doi: 10.1203/00006450-198412000-00001.
During the early months of life, gains in length and weight are more rapid by formula-fed than by breast-fed infants and we and others have speculated that the greater gains of the formula-fed infants are the result of greater food intake. If overfeeding during early infancy resulted in establishment of habits of overeating, or if, for any other reason, diet-induced fatness in infancy persisted into childhood, we might be able to demonstrate differences in fatness in childhood related to mode of feeding (breast or bottle) during infancy. We therefore examined at age 8 years 469 children born in 1966-1971 who had been studied intensely in our unit from 8 to 112 days of age. At age 8 years there were no differences in indices of fatness related to mode of feeding during infancy. Serum concentrations of cholesterol at age 8 years were also of interest because of reports from animal studies that differences in feeding during early life may be responsible for subsequent differences in cholesterol homeostasis. Cholesterol concentrations at age 8 years did not demonstrate significant differences related to mode of feeding during infancy. It is possible, however, that age 8 years is too early for an effect to be demonstrated.
在生命的最初几个月里，配方奶喂养的婴儿在身长和体重方面的增长比母乳喂养的婴儿更快，我们和其他人推测，配方奶喂养婴儿增长更快是食物摄入量更大的结果。如果婴儿早期过度喂养导致养成暴饮暴食的习惯，或者由于任何其他原因，婴儿期因饮食导致的肥胖持续到儿童期，那么我们或许能够证明儿童期的肥胖程度与婴儿期的喂养方式（母乳喂养或奶瓶喂养）有关。因此，我们对1966年至1971年出生、在8至112日龄时在我们单位接受深入研究的469名儿童进行了8岁时的检查。8岁时，与婴儿期喂养方式相关的肥胖指标没有差异。8岁时的血清胆固醇浓度也受到关注，因为动物研究报告表明，生命早期喂养方式的差异可能导致随后胆固醇稳态的差异。8岁时的胆固醇浓度没有显示出与婴儿期喂养方式相关的显著差异。然而，有可能8岁还太早，无法显示出影响。
