核小体核心的螺旋模型。
The helical model of the nucleosome core.
作者信息
Trifonov E
出版信息
Nucleic Acids Res. 1978 Apr;5(4):1371-80. doi: 10.1093/nar/5.4.1371.
Abstract
A model of the nucleosome core is proposed based on a topologically linear array of histones attached sequentially to DNA. The linear complex folds helically forming a spring-like particle. Different variants of the particle are discussed (cylindrical springs with and without histone-histone contacts between turns of the helix, solenoidal spring). The model is consistent with known data about the nucleosome structure. Histones H3 and H4 have a special role in the model which is related also to the superstructure of chromatin.
摘要
基于与DNA顺序连接的组蛋白拓扑线性阵列，提出了核小体核心模型。线性复合物螺旋折叠形成弹簧状颗粒。讨论了该颗粒的不同变体（螺旋各圈之间有和没有组蛋白-组蛋白接触的圆柱形弹簧、螺线管弹簧）。该模型与关于核小体结构的已知数据一致。组蛋白H3和H4在该模型中具有特殊作用，这也与染色质的超结构有关。
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引用本文的文献
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本文引用的文献
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Preparation of native chromatin and damage caused by shearing.制备天然染色质和剪切引起的损伤。
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Super-helical model for nucleohistone.核组蛋白的超螺旋模型
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7
The modification of deoxyribonucleohistone by trypsin and chymotrypsin.胰蛋白酶和糜蛋白酶对脱氧核糖核组蛋白的修饰作用。
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A complex of histones IIb2 and IV.组蛋白IIb2和IV的复合物。
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