Kanemaru Y, Aizawa K, Kagami T, Haraguchi K, Onaya T
Endocrinol Jpn. 1984 Dec;31(6):809-14. doi: 10.1507/endocrj1954.31.809.
A case of transient hypothyroidism in the course of hypokalemic myopathy is reported. A 69-year-old woman had severe muscle weakness and marked potassium deficiency associated with alkalosis during treatment with thiazide diuretics. The cause of muscle weakness proved to be hypokalemic myopathy confirmed by clinical findings and muscle biopsy. After the episode of hypokalemic myopathy, serum levels of thyroid hormone were lowered (T4; 3.8 micrograms/dl, T3; 54 ng/dl) and that of TSH was elevated (25.1 microU/ml). Antithyroid microsomal antibody was positive (1:25600) and anti-thyroglobulin antibody was negative. About one month after potassium supplement, her thyroid functions returned to normal, along with normalization of serum potassium level. This is the first documented case report of hypokalemic myopathy accompanied by transient hypothyroidism in a patient with autoimmune thyroiditis. We suggest that this transient hypothyroidism might be induced by hypokalemia during the course of autoimmune thyroiditis.
报告了1例低钾性肌病过程中出现短暂性甲状腺功能减退的病例。一名69岁女性在使用噻嗪类利尿剂治疗期间出现严重肌无力和明显的钾缺乏伴碱中毒。肌无力的原因经临床检查和肌肉活检证实为低钾性肌病。低钾性肌病发作后，甲状腺激素血清水平降低（T4；3.8微克/分升，T3；54纳克/分升），促甲状腺激素（TSH）水平升高（25.1微单位/毫升）。抗甲状腺微粒体抗体阳性（1:25600），抗甲状腺球蛋白抗体阴性。补钾约1个月后，她的甲状腺功能恢复正常，血清钾水平也恢复正常。这是自身免疫性甲状腺炎患者中首例记录在案的低钾性肌病伴短暂性甲状腺功能减退的病例报告。我们认为，这种短暂性甲状腺功能减退可能是自身免疫性甲状腺炎过程中低钾血症所致。
