Yoburn B C, Glusman M
Pharmacol Biochem Behav. 1984 Jun;20(6):829-33. doi: 10.1016/0091-3057(84)90001-7.
Male Long-Evans rats that consistently killed mice when food deprived were injected unilaterally in the lateral hypothalamus with 20 micrograms and 30 micrograms of the acetylcholine synthesis inhibitor hemicholinium-3 (HC-3) and saline in a counterbalanced order. Rats were evaluated 1, 2, 3, 24, 48 and 72 hours post-injection for effects on muricide, irritability and feeding. HC-3 suppressed muricide and feeding and produced a trend toward reduced irritability during the first three hours post-injection. These data indicate that modulation of cholinergic systems in the lateral hypothalamus influences several behaviors and not any one behavior specifically.
将一贯在食物匮乏时咬死小鼠的雄性长 Evans 大鼠，以平衡的顺序单侧注射 20 微克和 30 微克的乙酰胆碱合成抑制剂半胱胺酸三甲内盐（HC-3）以及生理盐水到下丘脑外侧。在注射后 1、2、3、24、48 和 72 小时评估大鼠对杀鼠行为、易怒性和进食的影响。HC-3 抑制了杀鼠行为和进食，并在注射后的前三小时呈现出易怒性降低的趋势。这些数据表明，下丘脑外侧胆碱能系统的调节会影响多种行为，而非特定的某一种行为。
