Allevato P A, Ohorodnik J M, Mezger E, Eisses J F
Am J Clin Pathol. 1984 Aug;82(2):247-52. doi: 10.1093/ajcp/82.2.247.
A 41-year-old diabetic woman developed endocarditis of the aortic valve caused by Paecilomyces javanicus six years after insertion of a porcine mitral valve heterograft. The patient died shortly after aortic valve replacement. Autopsy revealed vegetations of the aortic heterograft, valve ring abscess and ascending aortitis due to Paecilomyces. There was no involvement of the mitral valve heterograft. Lesions due to mycotic emboli were found in the kidneys, spleen, and brain. Cultures of the surgically removed aortic valve and of the kidney at autopsy produced rapid growth of P. javanicus. The gross and microscopic pathologic and cultural characteristics of this organism are described with a review of the literature. Previously reported cases of Paecilomyces endocarditis occurred only in prosthetic heart valves. This is the first known report of P. javanicus endocarditis of a native valve and its prosthetic heart valve heterograft.
一名41岁的糖尿病女性在植入猪二尖瓣异种移植物6年后发生了由爪哇拟青霉引起的主动脉瓣心内膜炎。患者在主动脉瓣置换术后不久死亡。尸检发现主动脉异种移植物有赘生物、瓣环脓肿以及由爪哇拟青霉引起的升主动脉炎。二尖瓣异种移植物未受累。在肾脏、脾脏和脑部发现了真菌栓子导致的病变。手术切除的主动脉瓣和尸检时的肾脏培养物中爪哇拟青霉生长迅速。本文描述了该微生物的大体和微观病理及培养特征，并对文献进行了综述。先前报道的拟青霉心内膜炎病例仅发生在人工心脏瓣膜。这是关于天然瓣膜及其人工心脏瓣膜异种移植物发生爪哇拟青霉心内膜炎的首例已知报道。
