Haldane E V, MacDonald J L, Gittens W O, Yuce K, van Rooyen C E
Can Med Assoc J. 1974 Nov 2;111(9):963-5, 968.
The third reported case of prosthetic valvular endocarditis caused by the fungus Paecilomyces is presented. The clinical course of the patient is discussed. The distinctive morphology of the fungus is described, together with the histologic and cytologic features found in the excised prosthetic valve and in the tissues at autopsy. Prosthetic valvular endocarditis presents a serious antibiotic and surgical problem in therapy. Despite antifungal antibiotics and valve replacement this patient died as a result of metastatic cerebral microabscesses and subarachnoid hemorrhage.
本文报告了第三例由拟青霉引起的人工瓣膜心内膜炎病例。讨论了该患者的临床病程。描述了该真菌独特的形态，以及在切除的人工瓣膜和尸检组织中发现的组织学和细胞学特征。人工瓣膜心内膜炎在治疗上是一个严重的抗生素和手术问题。尽管使用了抗真菌抗生素并进行了瓣膜置换，但该患者仍因转移性脑微脓肿和蛛网膜下腔出血而死亡。
