Kalish S B, Goldschmidt R, Li C, Knop R, Cook F V, Wilner G, Victor T A
Am J Clin Pathol. 1982 Aug;78(2):249-52. doi: 10.1093/ajcp/78.2.249.
The first reported case of Paecilomyces varioti endocarditis occurring on a porcine heterograft prosthesis is presented and the clinical and pathological features described in the four previously reported cases of prosthetic valvular endocarditis caused by this organism are reviewed. In each case, infection became apparent more than two months after cardiac surgery. Three of the four patients with infected aortic prosthesis developed outflow obstruction secondary to valvular vegetations. All patients died regardless of medical or surgical intervention. Appropriate therapy remains unknown.
本文报道了首例发生在猪异种移植人工心脏瓣膜上的变栖拟青霉心内膜炎病例，并回顾了此前报道的由该微生物引起的4例人工瓣膜心内膜炎的临床和病理特征。在每例病例中，感染在心脏手术后两个多月才显现出来。4例感染主动脉人工瓣膜的患者中有3例因瓣膜赘生物继发流出道梗阻。无论采取药物治疗还是手术干预，所有患者均死亡。目前尚不清楚合适的治疗方法。
