Ho K L, Allevato P A, King P, Chason J L
Acta Neuropathol. 1986;72(2):134-41. doi: 10.1007/BF00685975.
A 41-year-old diabetic woman developed Paecilomyces javanicus endocarditis and subsequent cerebral fungal embolism and vasculitis with massive infarction and hemorrhage 6 years after a mitral valve replacement with porcine heterograft. The organism was identified by the culture from the infected brain tissue and aortic valve. Cerebral infection due to fungus Paecilomyces is rare. This report documents the cerebral manifestations of fungus Paecilomyces javanicus and describes for the first time the ultrastructure of such an organism obtained from the infected tissue. Their ultrastructural findings, similar to those described in Paecilomyces farinosus derived from culture, include a double-layered cell wall, a triple unit plasma membrane, abundant cytoplasmic lipid droplets, vacuoles, membranous profiles and septal formation. This report further demonstrates hyphae with packed 50A filaments and granulofibrillary material and features suggestive of intrahyphal hyphae, not previously described in fungus Paecilomyces.
一名41岁的糖尿病女性在接受猪异种移植二尖瓣置换术后6年，发生了爪哇拟青霉性心内膜炎，随后出现脑真菌栓塞和血管炎，并伴有大面积梗死和出血。通过对感染的脑组织和主动脉瓣进行培养鉴定出了该病原体。由拟青霉引起的脑部感染较为罕见。本报告记录了爪哇拟青霉的脑部表现，并首次描述了从感染组织中获取的该病原体的超微结构。它们的超微结构发现与来源于培养物的粉状拟青霉中所描述的相似，包括双层细胞壁、三联体质膜、丰富的细胞质脂滴、液泡、膜性结构和隔膜形成。本报告进一步展示了含有紧密排列的50A细丝和颗粒状纤维物质的菌丝，以及提示有菌丝内菌丝的特征，这在拟青霉中此前未曾描述过。
