洋葱伯克霍尔德氏菌产生的两种新型抗生素，洋葱菌素A和洋葱菌素B。

Cepacin A and cepacin B, two new antibiotics produced by Pseudomonas cepacia.

作者信息

Parker W L, Rathnum M L, Seiner V, Trejo W H, Principe P A, Sykes R B

出版信息

J Antibiot (Tokyo). 1984 May;37(5):431-40. doi: 10.7164/antibiotics.37.431.

DOI:10.7164/antibiotics.37.431

Abstract

Two new acetylenic antibiotics, cepacins A and B, have been isolated from the fermentation broth of Pseudomonas cepacia SC 11,783 and assigned structures 1 and 2. Cepacin A has good activity against staphylococci (MIC 0.2 micrograms/ml) but weak activity against streptococci (MIC 50 micrograms/ml) and the majority of Gram-negative organisms (MIC values 6.3 approximately greater than 50 micrograms/ml). Cepacin B has excellent activity against staphylococci (MIC less than 0.05 micrograms/ml) and some Gram-negative organisms (MIC values 0.1 approximately greater than 50 micrograms/ml).

摘要

从洋葱伯克霍尔德菌SC 11783的发酵液中分离出两种新的炔类抗生素，即洋葱霉素A和B，并确定其结构分别为1和2。洋葱霉素A对葡萄球菌有良好活性（MIC为0.2微克/毫升），但对链球菌活性较弱（MIC为50微克/毫升），对大多数革兰氏阴性菌活性也较弱（MIC值为6.3至大于50微克/毫升）。洋葱霉素B对葡萄球菌有优异活性（MIC小于0.05微克/毫升），对一些革兰氏阴性菌也有活性（MIC值为0.1至大于50微克/毫升）。