与诱变胺：3-N，N-乙酰氧基乙酰氨基-4,6-二甲基二吡啶并（1,2-a：3'，2'-d）咪唑进行体外反应所诱导的DNA构象变化。
Conformational changes induced in DNA by the in vitro reaction with the mutagenic amine: 3-N,N-acetoxyacetylamino-4,6-dimethyldipyrido (1,2-a: 3', 2'-d) imidazole.
作者信息
Hébert E, Loukakou B, Saint-Ruf G, Leng M
出版信息
Nucleic Acids Res. 1984 Nov 26;12(22):8553-66. doi: 10.1093/nar/12.22.8553.
Abstract
The conformation of synthetic or natural DNAs modified in vitro by covalent binding of N-AcO-A-Glu-P-3 was investigated by fluorescence and circular dichroism. In all cases, substitution occurs mainly on the C8 of guanine residues. In modified poly(dG-dC).poly(dG-dC) or poly(dA-dC).poly(dG-dT) in B conformation, A-Glu-P-3 residues interact strongly with the bases whereas in Z conformation these residues are largely exposed to the solvent and interact weakly with the bases. A-Glu-P-3 and N-acetyl-2-aminofluorene (AAF) residues are equally efficient to induce the B-Z transition of poly(dG-dC).poly(dG-dC) and of poly(dA-dC).poly(dG-dT). Modifications of poly(dG).poly(dC) and calf thymus DNA indicate strong interactions between A-Glu-P-3 and the bases.
摘要
通过荧光和圆二色性研究了通过N - AcO - A - Glu - P - 3的共价结合在体外修饰的合成或天然DNA的构象。在所有情况下，取代主要发生在鸟嘌呤残基的C8上。在处于B构象的修饰聚（dG - dC）.聚（dG - dC）或聚（dA - dC）.聚（dG - dT）中，A - Glu - P - 3残基与碱基强烈相互作用，而在Z构象中，这些残基大部分暴露于溶剂中并与碱基弱相互作用。A - Glu - P - 3和N - 乙酰基 - 2 - 氨基芴（AAF）残基在诱导聚（dG - dC）.聚（dG - dC）和聚（dA - dC）.聚（dG - dT）的B - Z转变方面同样有效。聚（dG）.聚（dC）和小牛胸腺DNA的修饰表明A - Glu - P - 3与碱基之间存在强烈相互作用。
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引用本文的文献
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Z-DNA conformation of N-2-acetylaminofluorene modified poly(dG-dC).poly(dG-dC) determined by reactivity with anti cytidine antibodies and minimized potential energy calculations.通过与抗胞嘧啶抗体反应及最小化势能计算确定的 N-2-乙酰氨基芴修饰的聚（dG-dC）·聚（dG-dC）的 Z-DNA 构象
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