Rasche B, Hochstrasser K, Albrecht G J, Ulmer W T
Respiration. 1983;44(6):397-402. doi: 10.1159/000194576.
Under physiological conditions human bronchial mucus contains an elastase-specific inhibitor which is quite different from hitherto known inhibitors: alpha 1-antitrypsin, HI-30, and BSI-TE. In bronchial mucus of 100 patients suffering from obstructive airway disease the amount of this inhibitor specific against elastase from both pancreas and polymorphonuclear neutrophilic leucocytes was measured. A group of 18 patients showed no inhibitor in their native mucus rather than free elastolytic activity. Another group of 82 patients had no elastolytic activity in their native mucus but free anti-elastolytic activity together with varying amounts of elastase-specific inhibitor bound to proteases. In a total of 20 cases from both groups the inhibitor was not detectable, neither in a free nor in a complexed form. Presuming that there is no hereditary deficiency involved, a strong importance of inactivating reactions such as oxidation is concluded.
在生理条件下，人类支气管黏液含有一种弹性蛋白酶特异性抑制剂，它与迄今已知的抑制剂有很大不同：α1-抗胰蛋白酶、HI-30和BSI-TE。对100例患有阻塞性气道疾病患者的支气管黏液中针对胰腺和多形核中性粒细胞弹性蛋白酶的这种抑制剂的含量进行了测定。一组18例患者的天然黏液中未显示抑制剂，而是具有游离弹性溶解活性。另一组82例患者的天然黏液中没有弹性溶解活性，但具有游离抗弹性溶解活性以及与蛋白酶结合的不同量的弹性蛋白酶特异性抑制剂。在两组共20例病例中，无论是游离形式还是复合形式，均未检测到抑制剂。假定不存在遗传缺陷，得出氧化等失活反应非常重要的结论。
