恶性黑色素瘤中的单核细胞和巨噬细胞。III. 外周血单核细胞对硝基蓝四氮唑的还原作用
Monocytes and macrophages in malignant melanoma. III. Reduction of nitroblue tetrazolium by peripheral blood monocytes.
作者信息
Hedley D W, Currie G A
出版信息
Br J Cancer. 1978 May;37(5):747-52. doi: 10.1038/bjc.1978.113.
Abstract
Peripheral-blood monocytes from normal individuals and from patients with malignant melanoma reduce nitroblue tetrazolium (NBT). A quantitative assay for dye reduction was applied to 25 healthy donors and 31 patients with malignant melanoma. NBT reduction expressed as dye reduction per monocyte was significantly impaired in patients with disseminated disease, and they responded poorly to a phagocytic stimulus. Monocytes from patients with micrometastatic disease, however, showed normal resting NBT reduction but, following exposure to a suspension of latex-polystyrene, showed significantly greater NBT reduction than those from normal individuals. Since NBT reduction is an indirect measure of intracellular hexose-monophosphate-shunt activity we conclude that the monocytes from patients with minimal disease are in some way activated.
摘要
来自正常个体和恶性黑色素瘤患者的外周血单核细胞可使硝基蓝四氮唑（NBT）还原。对25名健康供者和31名恶性黑色素瘤患者进行了染料还原定量检测。以每个单核细胞的染料还原量表示的NBT还原在播散性疾病患者中显著受损，且他们对吞噬刺激反应不佳。然而，微转移疾病患者的单核细胞在静息状态下NBT还原正常，但在接触乳胶聚苯乙烯悬液后，其NBT还原比正常个体的单核细胞显著增强。由于NBT还原是细胞内己糖磷酸旁路活性的间接指标，我们得出结论，疾病处于早期的患者的单核细胞在某种程度上被激活。
相似文献
1
Monocytes and macrophages in malignant melanoma. III. Reduction of nitroblue tetrazolium by peripheral blood monocytes.恶性黑色素瘤中的单核细胞和巨噬细胞。III. 外周血单核细胞对硝基蓝四氮唑的还原作用
Br J Cancer. 1978 May;37(5):747-52. doi: 10.1038/bjc.1978.113.
2
Monocytes and macrophages in malignant melanoma IV. Effects of C. parvum on monocyte function.恶性黑色素瘤中的单核细胞和巨噬细胞IV. 微小隐孢子虫对单核细胞功能的影响
Br J Cancer. 1979 May;39(5):558-65. doi: 10.1038/bjc.1979.101.
3
Cell damage and dye reduction in the quantitative nitroblue tetrazolium (NBT) test.定量硝基蓝四氮唑（NBT）试验中的细胞损伤与染料还原
Clin Exp Immunol. 1975 Feb;19(2):309-18.
4
5
Functional evaluation of human neutrophils. Is the bactericidal activity correlated with nitroblue tetrazolium reduction?人类中性粒细胞的功能评估。杀菌活性与硝基蓝四氮唑还原反应相关吗？
J Investig Allergol Clin Immunol. 1992 May-Jun;2(3):146-53.
6
Ability of peripheral blood neutrophils from patients with infectious bronchial asthma to engulf latex particles and reduce nitroblue tetrazolium.
Arch Immunol Ther Exp (Warsz). 1988;36(1):55-9.
7
Cellular and humoral factors involvement in the enhanced NBT reduction by neutrophil leucocytes of newborn infants.
Acta Paediatr Scand. 1977 Sep;66(5):549-52. doi: 10.1111/j.1651-2227.1977.tb07945.x.
8
Study of phagocytic function with a quantitative nitroblue-Tetrazolium (NBT) reduction test in diabetes mellitus.糖尿病患者吞噬功能的定量硝基蓝四氮唑（NBT）还原试验研究
Arch Dermatol Res. 1980;268(3):283-8. doi: 10.1007/BF00404290.
9
Activation of human monocytes for nitroblue tetrazolium reduction and the suppression of lymphocyte response to mitogens.人单核细胞对硝基蓝四氮唑还原的激活作用以及淋巴细胞对有丝分裂原反应的抑制作用。
Clin Exp Immunol. 1980 Aug;41(2):309-16.
10
[Use of the leukocyte nitroblue tetrazolium reduction test in the differential diagnosis of infectious endocarditis and rheumatism].
Revmatologiia (Mosk). 1986 Jan-Mar(1):35-9.
引用本文的文献
1
Prospective associations of leucocyte subtypes and obesity with the risk of developing cutaneous malignant melanoma in the UK Biobank cohort.英国生物库队列中白细胞亚型和肥胖与皮肤恶性黑色素瘤发病风险的前瞻性关联。
BMC Cancer. 2024 May 23;24(1):625. doi: 10.1186/s12885-024-12344-0.
2
Effect of autologous and homologous serum and circulating immune complexes on monocyte functions of patients with solid tumours.自体和同源血清及循环免疫复合物对实体瘤患者单核细胞功能的影响。
Clin Exp Immunol. 1980 Aug;41(2):326-35.
3
Activation of human monocytes for nitroblue tetrazolium reduction and the suppression of lymphocyte response to mitogens.人单核细胞对硝基蓝四氮唑还原的激活作用以及淋巴细胞对有丝分裂原反应的抑制作用。
Clin Exp Immunol. 1980 Aug;41(2):309-16.
4
"Activated" monocytes in gastric cancer patients. I. Increased Fc receptor expression, antibody-dependent cellular cytotoxicity and NBT reduction.胃癌患者体内“活化”的单核细胞。I. 增强的Fc受体表达、抗体依赖性细胞毒性及NBT还原反应
J Cancer Res Clin Oncol. 1982;104(1-2):181-90. doi: 10.1007/BF00402066.
5
Monocyte function in cirrhosis.肝硬化中的单核细胞功能。
J Clin Pathol. 1982 Sep;35(9):972-9. doi: 10.1136/jcp.35.9.972.
6
Decrease in the phagocytic activity of peripheral monocytes in patients treated with human interferon-alpha.接受人α干扰素治疗的患者外周血单核细胞吞噬活性降低。
Cancer Immunol Immunother. 1982;13(3):149-52. doi: 10.1007/BF00205379.
7
Disordered function of mononuclear phagocytes in malignant disease.恶性疾病中单核吞噬细胞的功能紊乱
J Clin Pathol. 1983 Mar;36(3):316-23. doi: 10.1136/jcp.36.3.316.
8
A quantitative and qualitative study of blood monocytes in patients with bronchogenic carcinoma.支气管源性癌患者血液单核细胞的定量与定性研究。
Cancer Immunol Immunother. 1982;13(2):93-7. doi: 10.1007/BF00205307.
9
10
Monocytes and macrophages in malignant melanoma IV. Effects of C. parvum on monocyte function.恶性黑色素瘤中的单核细胞和巨噬细胞IV. 微小隐孢子虫对单核细胞功能的影响
Br J Cancer. 1979 May;39(5):558-65. doi: 10.1038/bjc.1979.101.
本文引用的文献
1
Activation of human blood monocytes by products of sensitized lymphocytes.致敏淋巴细胞产物对人血单核细胞的激活作用。
J Clin Invest. 1974 Feb;53(2):559-64. doi: 10.1172/JCI107590.
2
Leukocyte oxidase: defective activity in chronic granulomatous disease.白细胞氧化酶：慢性肉芽肿病中的活性缺陷
Science. 1967 Feb 17;155(3764):835-6. doi: 10.1126/science.155.3764.835.
3
The histochemical nitroblue tetrazolium reduction test in the differential diagnosis of acute infections.
Pediatrics. 1971 Aug;48(2):259-67.
4
Cytochemical identification of monocytes and granulocytes.单核细胞和粒细胞的细胞化学鉴定。
Am J Clin Pathol. 1971 Mar;55(3):283-90. doi: 10.1093/ajcp/55.3.283.
5
Abnormal monocyte chemotactic response in cancer patients.癌症患者单核细胞趋化反应异常。
J Natl Cancer Inst. 1974 Apr;52(4):1091-9. doi: 10.1093/jnci/52.4.1091.
6
7
The mechanism of the entry of dye into neutrophils in the nitroblue tetrazolium (NBT) test.在硝基蓝四氮唑（NBT）试验中染料进入中性粒细胞的机制。
Clin Sci Mol Med. 1973 Dec;45(6):817-26. doi: 10.1042/cs0450817.
8
Quantitative nitroblue tetrazolium test in chronic granulomatous disease.慢性肉芽肿病的定量硝基蓝四氮唑试验
N Engl J Med. 1968 May 2;278(18):971-6. doi: 10.1056/NEJM196805022781801.
9
Infection and nitroblue-tetrazolium reduction by neutrophils. A diagnostic acid.中性粒细胞的感染与硝基蓝四氮唑还原反应。一种诊断性酸。
Lancet. 1968 Sep 7;2(7567):532-4. doi: 10.1016/s0140-6736(68)92406-9.
10
Polymorphonuclear leukocytes stimulation by immune complexes. Assessment by nitroblue tetrazolium dye reduction.
Eur J Immunol. 1973 Aug;3(8):465-70. doi: 10.1002/eji.1830030803.
Zotero 插件