Jalava S, Heizmann P, Kylmämaa T
Scand J Rheumatol Suppl. 1983;48:11-2. doi: 10.3109/03009748309095334.
Concentrations of carprofen in the serum and the synovial fluid were determined in 13 patients with classical or confirmed rheumatoid arthritis. Four hours after the oral administration of 100 mg of carprofen, as one capsule, concentrations in the synovial fluid were found to be between 3.5 micrograms/ml and 9.7 micrograms/ml, with a mean value (+/- SD) of 6.2 +/- 1.4 micrograms/ml, and concentrations in the serum were between 4.7 micrograms/ml and 14.8 micrograms/ml, with a mean value of 9.8 +/- 2.9 micrograms/ml. The carprofen concentrations in synovial fluid varied from 36.3 to 103.0% of those in serum, with a mean value of 65.0 +/- 14.4%. There is a highly significant correlation between carprofen concentrations in the serum and the synovial fluid.
对13例典型或确诊类风湿性关节炎患者的血清和滑液中卡洛芬浓度进行了测定。口服100mg卡洛芬（作为一粒胶囊）4小时后，滑液中的浓度在3.5微克/毫升至9.7微克/毫升之间，平均值（±标准差）为6.2±1.4微克/毫升，血清中的浓度在4.7微克/毫升至14.8微克/毫升之间，平均值为9.8±2.9微克/毫升。滑液中卡洛芬浓度为血清中浓度的36.3%至103.0%，平均值为65.0±14.4%。血清和滑液中卡洛芬浓度之间存在高度显著的相关性。
