Kinsman O S, McKenna R, Noble W C
J Med Microbiol. 1983 May;16(2):215-20. doi: 10.1099/00222615-16-2-215.
We investigated the association between phenotypes of histocompatability antigen (HLA) and nasal carriage of Staphylococcus aureus in two populations--healthy laboratory workers and patients attending an outpatients' clinic. When data from the two sources were pooled, it was evident that the presence of HLA-DR3 was associated with carriage, and the presence of HLA-DR2, HLA-DR1 and HLA-Bw35 with lack of carriage. However, since each person may have two antigenic specificities encoded at the HLA-A, the HLA-B, and the HLA-DR loci, the carriage of the organism was analysed for paired combinations of the more frequent phenotypes. For example, the lack of carriage evident with HLA-DR1 was more marked with the DR1-A11 and DR1-B7 combinations while the predisposition towards carriage shown with HLA-DR3 was more marked with the DR3-DR5 combination. The importance of the analysis of antigen combinations is discussed in relation to association of single antigens with carriage of S. aureus.
我们在两组人群中研究了组织相容性抗原（HLA）表型与金黄色葡萄球菌鼻腔携带之间的关联，这两组人群分别是健康的实验室工作人员和门诊患者。当将来自这两个来源的数据汇总时，很明显HLA - DR3的存在与携带相关，而HLA - DR2、HLA - DR1和HLA - Bw35的存在与未携带相关。然而，由于每个人在HLA - A、HLA - B和HLA - DR位点可能编码有两种抗原特异性，因此针对更常见表型的配对组合分析了该微生物的携带情况。例如，HLA - DR1显示的未携带情况在DR1 - A11和DR1 - B7组合中更为明显，而HLA - DR3显示的携带倾向在DR3 - DR5组合中更为明显。结合单一抗原与金黄色葡萄球菌携带的关联讨论了抗原组合分析的重要性。
