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分散在两条或更多条染色体上的多基因家族的群体遗传学。

Population genetics of multigene families that are dispersed into two or more chromosomes.

作者信息

Ohta T, Dover G A

出版信息

Proc Natl Acad Sci U S A. 1983 Jul;80(13):4079-83. doi: 10.1073/pnas.80.13.4079.

Abstract

The evolution of multigene families whose members are dispersed into two or more nonhomologous chromosomes is studied from the standpoint of population genetics. By using a simple model of gene conversion, equilibrium and transient properties of the probability of identity of genes belonging to the family are investigated. Also, the time until fixation of a mutant belonging to a subdivided multigene family is studied by an approximation method. It is shown that dispersion of the family into two or more chromosomes has a relatively minor effect on the extent of identity between genes, unless the conversion rate between genes on nonhomologous chromosomes is extremely low, or unless the number of nonhomologous chromosomes on which gene members are dispersed is large.

摘要

从群体遗传学的角度研究了其成员分散在两条或更多条非同源染色体上的多基因家族的进化。通过使用一个简单的基因转换模型,研究了属于该家族的基因同一性概率的平衡和瞬态特性。此外,还通过一种近似方法研究了属于细分多基因家族的突变体固定所需的时间。结果表明,除非非同源染色体上基因之间的转换率极低,或者基因成员分散在其上的非同源染色体数量很大,否则家族分散到两条或更多条染色体上对基因之间的同一性程度影响相对较小。

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