神经生长因子：体外对多形核白细胞趋化性的刺激作用
Nerve growth factor: stimulation of polymorphonuclear leukocyte chemotaxis in vitro.
作者信息
Gee A P, Boyle M D, Munger K L, Lawman M J, Young M
出版信息
Proc Natl Acad Sci U S A. 1983 Dec;80(23):7215-8. doi: 10.1073/pnas.80.23.7215.
Abstract
Topical application of mouse nerve growth factor (NGF) to superficial skin wounds of mice has previously been shown to accelerate the rate of wound contraction. Results of the present study reveal that NGF in the presence of plasma is also chemotactic for human polymorphonuclear leukocytes in vitro, and the concentration of NGF required for this effect is similar to that which stimulates ganglionic neurite outgrowth. This property does not arise from liberation of the C5a fragment of complement, nor does it require the known enzymic activity of NGF. (NGF inactivated with diisopropyl fluorophosphate is equally active.) We conclude that NGF can display biological effects on cells of nonneural origin and function, and this feature might play a role in the early inflammatory response to injury.
摘要
先前已表明，将小鼠神经生长因子（NGF）局部应用于小鼠的浅表皮肤伤口可加速伤口收缩速率。本研究结果显示，在有血浆存在的情况下，NGF在体外对人多形核白细胞也具有趋化作用，产生这种作用所需的NGF浓度与刺激神经节神经突生长的浓度相似。此特性并非由补体C5a片段的释放引起，也不需要NGF已知的酶活性。（用氟磷酸二异丙酯灭活的NGF同样具有活性。）我们得出结论，NGF可对非神经来源和功能的细胞发挥生物学作用，且这一特性可能在对损伤的早期炎症反应中起作用。
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